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| 04:30 Tigres de la UANL – Deportivo Toluca 0:0 | 2.19 | 3.15 | 3.34 | 1X | 1-0 | U |
| 06:30 Cruz Azul – Puebla 1:0 | 1.53 | 4.15 | 5.60 | 1 | 2-1 | O |
| 06:30 Tijuana – Atletico San Luis 1:1 | 2.06 | 3.30 | 3.51 | 1 | 2-1 | O |
|
| 09:30 Sydney – Wellington Phoenix 0:2 | 1.60 | 4.55 | 5.17 | 1 | 2-1 | O |
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| 14:00 Fajr Sepasi – Persepolis 2:1 | 5.73 | 2.88 | 1.73 | 2X | 0-2 | U |
| 14:00 Shams Azar Qazvin – Esteghlal Khuzestan 0:0 | 1.97 | 2.80 | 4.04 | 2X | 0-2 | U |
|
| 14:00 BB Erzurum – Amedspor 2:0 | 2.61 | 2.89 | 2.62 | 1X | 2-1 | U |
|
| 14:45 Den Bosch – MVV Maastricht 1:2 | 1.54 | 4.25 | 5.31 | X2 | 0-1 | O |
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| 14:45 Heerenveen – Groningen 3:2 | 2.24 | 3.32 | 3.40 | 1X | 2-1 | U |
|
| 15:00 Aluminium Arak – Gol Gohar 1:2 | 3.43 | 2.75 | 2.38 | 2X | 0-2 | U |
|
| 15:00 Parma – Genoa 0:0 | 2.93 | 2.90 | 3.04 | 2X | 0-2 | U |
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| 15:00 Balestier Khalsa – Hougang United 2:3 | 1.91 | 4.25 | 2.94 | 1 | 3-1 | O |
| 15:00 Geylang International – Lion City Sailors 0:3 | 6.67 | 5.20 | 1.32 | 2 | 1-3 | O |
|
| 15:00 Kasimpasa – Antalyaspor 0:0 | 2.13 | 3.41 | 3.72 | X2 | 1-2 | U |
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| 16:00 Gent – Anderlecht 4:2 | 3.09 | 3.40 | 2.33 | X2 | 0-1 | U |
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| 16:00 1. Kaiserslautern – Hannover 96 3:1 | 3.24 | 3.45 | 2.13 | 2X | 0-2 | U |
| 16:00 Holstein – Paderborn 07 2:0 | 3.02 | 3.35 | 2.28 | 1X | 1-0 | U |
| 16:00 VfL Bochum – Darmstadt 98 3:3 | 2.49 | 3.34 | 2.70 | 1X | 2-1 | O |
|
| 16:00 Esteghlal – Tractor Tabriz 0:0 | 2.75 | 2.85 | 2.75 | 2X | 0-2 | U |
|
| 16:30 Getafe – Valencia 0:1 | 2.80 | 2.80 | 3.34 | 1X | 2-0 | U |
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| 16:30 Mirandes – Andorra Andorra la Vella 1:2 | 2.86 | 3.22 | 2.62 | 1X | 2-0 | U |
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| 16:30 Servette – Zurich 1:1 | 1.81 | 3.54 | 4.30 | 1 | 2-1 | O |
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| 16:30 Boluspor – Sarıyer 1:2 | 2.27 | 3.20 | 2.89 | 1 | 2-0 | U |
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| 16:35 Baniyas – Al Bataeh 1:1 | 2.11 | 3.24 | 3.16 | X2 | 0-3 | U |
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| 16:45 Fajr Sepasi – Persepolis 2:1 | 4.15 | 3.11 | 1.83 | 2X | 0-2 | U |
|
| 17:00 Almere City – De Graafschap 2:0 | 1.95 | 4.05 | 3.20 | 1X | 1-3 | O |
| 17:00 Waalwijk – Dordrecht 1:1 | 1.66 | 4.10 | 4.42 | X2 | 1-2 | O |
|
| 17:00 Heracles Almelo – Twente 0:2 | 6.02 | 4.38 | 1.54 | 1X | 2-1 | O |
| 17:00 Volendam – Utrecht 2:1 | 4.36 | 3.84 | 1.81 | 1X | 3-0 | U |
|
| 17:00 Csikszereda Miercurea Ciuc – Botosani 1:0 | 4.68 | 3.52 | 1.74 | 1X | 2-1 | O |
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| 17:30 AC Omonia – Anorthosis 2:0 | 1.33 | 4.95 | 8.40 | 1 | 2-1 | U |
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| 17:30 Wolverhampton Wanderers – Newcastle United 0:0 | 4.52 | 4.11 | 1.82 | 2 | 1-2 | O |
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| 17:30 Strasbourg – Metz 2:1 | 1.47 | 4.92 | 7.50 | 1 | 2-1 | O |
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| 17:30 Bologna 1909 – Fiorentina 1:2 | 2.44 | 3.40 | 3.21 | 1X | 2-1 | U |
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| 17:30 Delfino Pescara 1936 – Modena 0:2 | 4.94 | 3.75 | 1.67 | 1X | 2-1 | U |
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| 17:30 Lusitania Lourosa – Marítimo 0:4 | 4.33 | 3.25 | 1.87 | 2X | 0-2 | U |
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| 17:30 Genclerbirligi – Samsunspor 1:1 | 2.80 | 3.16 | 2.80 | X2 | 1-2 | U |
| 17:30 Kocaelispor – Trabzonspor 1:2 | 2.64 | 3.28 | 2.87 | X2 | 0-3 | U |
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| 18:00 VfB Stuttgart – Union Berlin 1:1 | 1.66 | 4.26 | 5.64 | 1 | 2-1 | O |
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| 18:30 FCV Dender EH – Royal Antwerp 1:0 | 3.15 | 3.17 | 2.41 | X2 | 1-2 | U |
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| 18:30 AEK Larnaca – Freedom24 Krasava 2:1 | 1.23 | 5.60 | 12.10 | 1 | 2-1 | O |
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| 18:30 AEL 1964 – Aris 1:0 | 4.05 | 2.95 | 2.08 | 2X | 0-2 | U |
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| 18:45 Al Hazm Rass – Al-Qadisiyah 1:5 | 6.22 | 4.35 | 1.41 | 1X | 3-0 | U |
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| 18:45 Atletico Madrid – Deportivo Alaves 1:0 | 1.41 | 5.08 | 9.00 | X2 | 1-2 | O |
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| 18:45 Racing de Santander – Las Palmas 4:1 | 2.27 | 3.27 | 3.38 | 1X | 2-1 | U |
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| 19:00 Santa Clara – Famalicao 0:1 | 3.08 | 3.02 | 2.66 | 1X | 2-0 | U |
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| 19:00 Basel – Sion 1:1 | 1.75 | 3.80 | 4.32 | 1 | 2-1 | O |
| 19:00 Grasshopper Club Zurich – Thun 1:3 | 3.26 | 3.35 | 2.16 | 1X | 2-1 | O |
|
| 19:15 Eindhoven – Willem II 0:2 | 2.97 | 3.60 | 2.18 | 1X | 2-1 | U |
|
| 19:15 Feyenoord – Sparta Rotterdam 1:0 | 1.37 | 5.24 | 8.10 | 1 | 2-1 | O |
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| 19:15 CFR Cluj – Otelul Galati 1:0 | 2.19 | 3.02 | 3.50 | 1 | 2-1 | U |
|
| 19:15 Al Sharjah – Al Ittihad Kalba 3:1 | 1.61 | 3.68 | 4.86 | 1 | 2-1 | O |
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| 19:30 Umraniyespor – Serikspor 5:0 | 1.47 | 4.10 | 5.70 | 1 | 2-1 | O |
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| 19:45 Nantes – Paris 1:2 | 2.91 | 3.27 | 2.73 | X2 | 1-2 | U |
| 19:45 Stade Rennais – Le Havre 1:1 | 1.67 | 4.26 | 5.53 | 1 | 2-1 | U |
|
| 19:45 Citta di Palermo – Spezia Calcio 1:0 | 1.73 | 3.64 | 4.66 | 1 | 2-0 | U |
|
| 20:00 Aston Villa – Everton 0:1 | 1.69 | 4.12 | 5.54 | 1 | 2-1 | O |
|
| 20:00 Augsburg – Freiburg 2:2 | 2.78 | 3.34 | 2.82 | 1X | 2-1 | U |
|
| 20:30 Apollon Limassol – APOEL 2:1 | 2.75 | 3.04 | 2.59 | 1X | 2-1 | U |
|
| 20:30 P.A.O.K. – OFI Crete 3:0 | 1.14 | 7.70 | 15.50 | 1 | 2-1 | O |
|
| 20:30 Torino – Roma 0:2 | 4.24 | 3.39 | 2.06 | 2X | 0-2 | U |
|
| 20:30 Alanyaspor – Fenerbahce 2:3 | 5.61 | 4.31 | 1.61 | 2 | 0-3 | U |
|
| 21:00 R. Charleroi – Standard Liege 2:0 | 1.99 | 3.22 | 4.30 | 1X | 2-0 | U |
|
| 21:00 Al-Riyadh SC – Al-Taawon 1:3 | 3.68 | 3.38 | 1.88 | 1X | 3-0 | U |
| 21:00 Neom SC – Al-Hilal Riyadh 1:2 | 5.84 | 4.55 | 1.41 | 2 | 1-2 | O |
|
| 21:00 Celta – Rayo Vallecano 3:0 | 2.00 | 3.39 | 4.52 | 2X | 0-2 | U |
|
| 21:00 Albacete Balompie – Cadiz 1:0 | 2.10 | 3.52 | 3.55 | 1X | 2-1 | U |
| 21:00 Burgos – Huesca 1:0 | 2.11 | 3.00 | 4.26 | 1X | 2-0 | U |
|
| 21:30 Pumas UNAM – Leon 1:1 | 1.92 | 3.52 | 3.72 | 1 | 2-1 | U |
|
| 21:30 Tondela – Braga 0:1 | 6.50 | 4.02 | 1.59 | 2 | 0-3 | U |
|
| 21:45 Sint-Truidense – Oud-Heverlee Leuven 1:0 | 1.76 | 3.70 | 4.76 | 1 | 2-1 | U |
|
| 22:00 Dinamo Bucuresti – Universitatea Cluj 1:0 | 2.00 | 3.18 | 3.86 | 2X | 0-2 | U |
|
| 22:30 AEK Athens – Panathinaikos 4:0 | 2.02 | 3.28 | 3.74 | 1 | 2-0 | U |
|
| 23:15 Lyon – Stade Brestois 29 2:1 | 1.71 | 4.12 | 5.34 | 1 | 2-1 | U |
|
| 23:15 Milan – Lecce 1:0 | 1.31 | 5.69 | 12.90 | 1 | 2-1 | O |
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| 23:30 Real Sociedad – Barcelona 2:1 | 5.13 | 4.72 | 1.64 | 2 | 1-2 | O |
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| 23:30 Cordoba – Malaga 0:1 | 2.09 | 3.38 | 3.74 | 1 | 2-1 | U |
|
| 00:00 Vitoria Guimaraes – Porto 0:1 | 7.48 | 4.32 | 1.50 | 2 | 1-2 | U |
|
| 02:30 Santos Laguna – Juarez 2:2 | 2.61 | 3.36 | 2.51 | 1X | 2-1 | U |
