|
| 03:45 Argentinos Juniors – Estudiantes de Rio Cuarto 3:0 | 1.36 | 4.48 | 10.90 | 1X | 1-0 | U |
| 03:45 Rosario Central – Racing Club de Avellaneda 0:0 | 1.98 | 3.10 | 4.41 | X2 | 0-1 | U |
|
| 04:30 Cavalry – Supra du Quebec 2:1 | 1.39 | 4.45 | 6.34 | 1 | 2-1 | O |
|
| 18:00 Dukagjini – Lugano 1:5 | 5.79 | 4.20 | 1.51 | 2 | 1-2 | O |
|
| 18:30 Kairat – AC Omonia 2:0 | 2.14 | 3.36 | 3.48 | X2 | 0-1 | U |
|
| 18:30 Dinamo Samarqand – Kokand 1912 3:2 | 1.67 | 3.82 | 4.78 | 1 | 1-0 | U |
|
| 19:00 Mikkelin Palloilijat – KaPa 2:1 | 1.95 | 3.48 | 3.34 | 1X | 1-0 | U |
|
| 19:30 Zalgiris Kaunas – KI Klaksvik 1:0 | 1.76 | 3.58 | 4.88 | X2 | 1-2 | O |
| 20:30 Lech Poznan – AGF Aarhus 1:5 | 1.66 | 3.94 | 5.08 | 1 | 2-1 | O |
|
| 20:30 Copenhagen – Polissya Zhytomyr 2:1 | 1.63 | 4.05 | 4.70 | 1 | 2-1 | O |
|
| 21:00 Barracas Central – CA Aldosivi 1:0 | 2.35 | 2.83 | 3.64 | 1X | 2-1 | U |
|
| 21:00 CS Universitatea Craiova – Levski Sofia 2:2 | 1.97 | 3.40 | 4.00 | X2 | 1-2 | U |
| 21:00 Hapoel Be'er Sheva – Vikingur Reykjavik 2:0 | 1.66 | 4.12 | 4.83 | X2 | 1-2 | U |
| 21:30 Gornik Zabrze – Fenerbahce 1:1 | 6.28 | 4.42 | 1.55 | 2 | 1-2 | U |
| 21:30 Crvena Zvezda – Larne 5:0 | 1.06 | 15.00 | 23.00 | 1 | 4-1 | O |
| 21:45 Slovan Bratislava – Iberia 1999 1:1 | 1.34 | 5.35 | 8.55 | 1 | 2-1 | O |
|
| 22:00 Rapid Wien – Santa Coloma 6:2 | 1.09 | 9.60 | 18.00 | 1 | 2-1 | O |
|
| 22:30 Sportivo Luqueno – Sportivo Trinidense 1:4 | 3.22 | 2.88 | 2.43 | X2 | 0-1 | U |
|
| 23:30 Defensa y Justicia – Deportivo Riestra 2:1 | 2.28 | 2.90 | 3.70 | X2 | 1-2 | U |
|
| 23:30 Botafogo de Futebol e Regatas – Gremio Porto Alegrense 0:0 | 1.74 | 3.64 | 5.19 | 1 | 2-1 | O |
| 23:30 Chapecoense – CR Vasco da Gama 0:0 | 3.17 | 3.17 | 2.43 | X2 | 0-1 | U |
| 23:30 Clube Atletico Mineiro – Red Bull Bragantino 0:0 | 2.20 | 3.35 | 3.46 | 1X | 1-0 | U |
| 23:30 Sao Paulo – Santos 0:0 | 2.04 | 3.47 | 3.78 | 1X | 1-0 | U |
|
| 01:00 Club Nacional Asuncion – Club Olimpia 2:0 | 3.16 | 2.81 | 2.51 | 1X | 1-0 | U |
|
| 01:45 Gimnasia y Esgrima La Plata – River Plate Buenos Aires 1:0 | 3.84 | 3.06 | 2.15 | 1X | 2-1 | U |
|
| 02:00 Mirassol – Clube do Remo 2:1 | 1.72 | 3.76 | 5.14 | 1 | 2-1 | U |
| 02:00 Sport Club Internacional – Flamengo 1:1 | 4.42 | 3.48 | 1.89 | X2 | 1-2 | U |
|
| 02:30 Pittsburgh Riverhounds – Tulsa 0:1 | 1.85 | 3.24 | 4.00 | X2 | 0-1 | U |
| 03:00 Louisville City – Birmingham Legion 2:1 | 1.35 | 4.85 | 6.57 | 1 | 2-1 | O |
