|
| 04:00 Dallas – Minnesota United : | 2.28 | 3.74 | 3.08 | | | U | no |
| 04:00 Houston Dynamo – San Diego : | 2.30 | 3.76 | 3.02 | | | U | no |
|
| 04:30 Atlas Guadalajara – Tigres de la UANL : | 3.70 | 3.48 | 1.94 | | | U | no |
| 04:30 Atletico San Luis – Santos Laguna : | 1.76 | 3.96 | 3.95 | | | U | no |
| 04:30 Mazatlan – Deportivo Toluca : | 5.84 | 4.50 | 1.47 | | | U | no |
|
| 05:00 Real Salt Lake – Inter Miami : | 2.54 | 3.82 | 2.66 | | | U | no |
| 06:00 Los Angeles – Colorado Rapids : | 1.45 | 4.97 | 7.12 | | | U | no |
| 06:00 San Jose Earthquakes – Austin : | 1.69 | 4.20 | 4.93 | | | U | no |
|
| 06:30 Club Necaxa – Guadalajara : | 4.80 | 4.05 | 1.62 | | | U | no |
| 06:30 Tijuana – Pachuca : | 3.08 | 3.40 | 2.20 | | | U | no |
|
| 18:00 Akron Tolyatti – Dynamo Makhachkala : | 2.69 | 3.20 | 3.02 | | | U | no |
|
| 20:15 Go Ahead Eagles – AZ Alkmaar : | 2.96 | 3.84 | 2.25 | | | U | no |
|
| 20:15 Akhmat – Baltika Kaliningrad : | 2.55 | 3.40 | 3.04 | | | U | no |
| 20:15 Spartak Moscow – Krasnodar : | 2.64 | 3.80 | 2.68 | | | U | no |
|
| 20:30 Levante UD – Sevilla : | 2.59 | 3.48 | 2.92 | | | U | no |
| 21:30 Rayo Vallecano – Espanyol : | 1.97 | 3.63 | 4.31 | | | U | no |
|
| 22:30 PSV Eindhoven – PEC Zwolle : | 1.22 | 7.32 | 12.10 | | | U | no |
|
| 23:00 Real Oviedo – Villarreal : | 4.06 | 3.74 | 1.99 | | | U | no |
