|
| 04:30 Cruz Azul – Puebla : | 1.29 | 5.25 | 9.25 | 1 | 2-1 | O |
| 06:30 Deportivo Toluca – Pumas UNAM : | 1.58 | 4.05 | 5.18 | 1 | 2-1 | O |
|
| 14:00 Bucheon 1995 – Anyang : | 2.88 | 2.97 | 2.58 | X2 | 0-1 | U |
| 14:00 Gwangju – Gimcheon Sangmu : | 4.37 | 3.50 | 1.81 | 2 | 1-2 | O |
| 14:00 Seoul – Pohang Steelers : | 1.82 | 3.42 | 4.42 | 1X | 2-1 | U |
|
| 19:30 Neftchi Baku – Dinamo Minsk : | 2.11 | 3.30 | 3.37 | 1X | 1-0 | U |
|
| 20:30 Bodo-Glimt – HamKam : | 1.09 | 11.60 | 21.00 | X2 | 2-2 | O |
| 20:30 Lillestrom – Viking : | 3.09 | 3.74 | 2.19 | 1X | 2-1 | O |
|
| 20:30 AC Omonia – Kairat : | 1.66 | 3.78 | 4.98 | 1 | 2-1 | U |
|
| 20:30 Bohemian Dublin – Ballkani : | 1.76 | 3.58 | 4.44 | 1X | 2-1 | U |
|
| 21:00 Levski Sofia – CS Universitatea Craiova : | 2.15 | 3.12 | 3.54 | 1X | 2-1 | U |
|
| 21:15 Istanbul BFK – Inter Turku : | 1.18 | 6.35 | 14.20 | 1X | 2-1 | U |
| 21:30 Vardar – Riga FC : | 2.88 | 3.35 | 2.34 | 1X | 2-1 | U |
| 22:00 Spartak Trnava – CSKA Sofia 1948 : | 2.35 | 3.18 | 3.00 | 1X | 1-0 | U |
|
| 22:30 Egnatia – Celje : | 3.48 | 3.45 | 2.04 | 1X | 2-1 | U |
|
| 22:30 Zeleznicar Pancevo – Braga : | 7.90 | 5.00 | 1.34 | 1X | 2-2 | U |
|
| 23:30 Botafogo de Futebol e Regatas – Santos : | 1.97 | 3.46 | 4.10 | X2 | 1-2 | U |
| 23:30 Chapecoense – Flamengo : | 7.70 | 4.58 | 1.44 | 2 | 1-2 | U |
| 23:30 Clube Atletico Mineiro – Bahia : | 2.19 | 3.40 | 3.44 | X2 | 0-1 | U |
| 23:30 Corinthians Paulista – Clube do Remo : | 1.58 | 3.93 | 6.38 | 1 | 2-1 | U |
| 23:30 Coritiba – Sociedade Esportiva Palmeiras : | 4.06 | 3.40 | 2.00 | 2 | 1-2 | O |
| 23:30 EC Vitoria Salvador – CR Vasco da Gama : | 2.49 | 3.27 | 2.99 | 1X | 2-1 | O |
| 23:30 Fluminense – Red Bull Bragantino : | 1.75 | 3.64 | 5.09 | X2 | 1-2 | O |
| 23:30 Mirassol – Gremio Porto Alegrense : | 2.15 | 3.42 | 3.52 | X2 | 1-2 | U |
| 23:30 Sao Paulo – Clube Atletico Paranaense : | 1.94 | 3.39 | 4.32 | X2 | 1-2 | U |
| 23:30 Sport Club Internacional – Cruzeiro Esporte Clube : | 2.35 | 3.36 | 3.15 | 1X | 1-0 | U |
| 02:00 Coritiba – Sociedade Esportiva Palmeiras : | 4.22 | 3.34 | 1.98 | X2 | 1-2 | O |
|
| 02:30 Lexington – Oakland Roots : | 1.85 | 3.56 | 3.61 | 1 | 2-1 | U |
|
| 03:00 Cincinnati – Vancouver Whitecaps : | 4.05 | 4.20 | 1.83 | 2 | 1-2 | O |
| 03:00 Columbus Crew – New York City : | 2.02 | 3.74 | 3.72 | X2 | 0-1 | U |
| 03:00 Inter Miami – Chicago Fire : | 2.12 | 4.21 | 3.10 | 1X | 2-1 | O |
| 03:00 New England Revolution – Toronto : | 1.94 | 3.80 | 3.93 | 1 | 2-1 | O |
| 03:00 Philadelphia Union – New York Red Bulls : | 1.79 | 4.21 | 4.26 | X2 | 1-2 | O |
