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| 03:45 Charlotte – Atlanta United : | 1.98 | 3.70 | 3.93 | 1 | 2-1 | O |
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| 04:00 Chapecoense – Flamengo : | 7.21 | 4.46 | 1.47 | 2 | 1-2 | U |
| 04:00 Sao Paulo – Clube Atletico Paranaense : | 2.05 | 3.27 | 4.03 | X2 | 1-2 | U |
| 04:00 Sport Club Internacional – Cruzeiro Esporte Clube : | 2.24 | 3.32 | 3.40 | 1X | 1-0 | U |
|
| 04:00 Austin – Seattle Sounders : | 3.45 | 3.74 | 2.11 | 1X | 2-1 | O |
| 04:00 Houston Dynamo – D.C. United : | 1.84 | 3.82 | 4.42 | 1 | 2-1 | U |
| 04:00 Nashville – CF Montreal : | 1.53 | 4.50 | 6.44 | 1 | 2-1 | O |
| 04:00 Sporting Kansas City – Minnesota United : | 3.47 | 3.88 | 2.06 | 1X | 2-1 | O |
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| 04:30 Colorado Springs Switchbacks – Miami : | 1.41 | 4.50 | 5.95 | 1 | 2-1 | O |
|
| 05:00 Colorado Rapids – San Diego : | 2.14 | 4.02 | 3.17 | X2 | 1-2 | O |
| 06:00 Los Angeles – Real Salt Lake : | 1.76 | 4.20 | 4.41 | 1 | 2-1 | O |
| 06:00 Los Angeles Galaxy – St. Louis City : | 2.00 | 3.93 | 3.62 | X2 | 1-2 | O |
| 06:00 Portland Timbers – Dallas : | 2.41 | 3.76 | 2.85 | X2 | 1-2 | O |
| 06:00 San Jose Earthquakes – Orlando City : | 1.57 | 4.99 | 5.15 | 1 | 3-1 | O |
|
| 16:30 Rakow Czestochowa – Valletta : | 1.11 | 8.40 | 30.00 | 1 | 4-1 | U |
| 16:30 Paksi – Panathinaikos : | 5.02 | 3.80 | 1.59 | 1X | 2-1 | U |
| 16:30 FCSB – Auda : | 8.40 | 4.50 | 1.31 | 1X | 2-2 | U |
| 16:30 LNZ – Gent : | 3.25 | 3.30 | 2.21 | 1X | 2-1 | U |
| 16:30 AEK Larnaca – Beitar Jerusalem : | 1.88 | 3.70 | 4.06 | 1 | 2-1 | U |
| 16:30 GAIS – Nordsjaelland : | 2.75 | 3.30 | 2.32 | X2 | 1-2 | U |
| 16:30 Hapoel Tel Aviv – Ludogorets 1945 : | 3.09 | 3.10 | 2.47 | X2 | 0-1 | U |
| 16:30 Polissya Zhytomyr – Copenhagen : | 8.40 | 4.50 | 1.31 | 2 | 0-3 | U |
| 16:30 Zeleznicar Pancevo – Braga : | 8.40 | 4.50 | 1.31 | 1X | 2-2 | U |
| 16:30 Dila Gori – Apollon Limassol : | 3.20 | 3.20 | 2.38 | 1X | 1-0 | U |
|
| 16:30 Tromso – Hradec Kralove : | 1.71 | 3.60 | 4.68 | 1 | 2-1 | O |
| 16:30 St. Gallen – Benfica : | 6.64 | 4.50 | 1.44 | 2 | 1-2 | O |
| 16:30 Besiktas – Midtjylland : | 1.81 | 3.55 | 4.19 | 1 | 2-1 | U |
| 16:30 Hammarby – Anderlecht : | 2.82 | 3.25 | 2.41 | 1X | 2-1 | O |
|
| 18:00 Malisheva – Hibernian : | 5.05 | 3.78 | 1.64 | 2 | 0-1 | U |
| 18:30 Alashkert – CFR Cluj : | 3.66 | 3.20 | 2.05 | 1X | 2-1 | U |
| 18:30 Liepaja – Austria Wien : | 7.80 | 4.65 | 1.37 | 1X | 2-0 | U |
| 19:00 Panevezys – Tobol Kostanay : | 3.21 | 3.40 | 2.14 | 1X | 1-0 | U |
| 19:30 Debreceni VSC – Pyunik : | 1.77 | 3.44 | 4.58 | 1 | 1-0 | U |
| 19:30 Dila Gori – Apollon Limassol : | 3.94 | 3.25 | 1.95 | X2 | 0-1 | U |
| 19:30 Flora Tallinn – The New Saints : | 2.26 | 3.54 | 2.87 | X2 | 0-1 | U |
| 19:30 HJK – Coleraine : | 1.37 | 4.80 | 7.42 | 1 | 2-1 | O |
| 19:30 Paide Linnameeskond – Zira : | 7.95 | 5.25 | 1.32 | 2 | 0-2 | U |
|
| 19:30 Qarabag – CSKA Sofia : | 1.59 | 3.80 | 5.69 | 1 | 2-1 | U |
|
| 20:00 AEK Larnaca – Beitar Jerusalem : | 2.01 | 3.36 | 3.59 | 1 | 2-1 | U |
| 20:00 Rakow Czestochowa – Valletta : | 1.10 | 8.00 | 24.00 | 1 | 4-1 | U |
| 20:00 DAC 1904 – Velez Mostar : | 1.25 | 5.50 | 11.00 | 1 | 1-0 | U |
| 20:00 Rigas Futbola skola – Vestri : | 1.02 | 13.00 | 46.00 | 1 | 2-1 | O |
| 20:30 GAIS – Nordsjaelland : | 2.72 | 3.44 | 2.38 | X2 | 1-2 | U |
| 20:30 Universitatea Cluj – Brann : | 3.16 | 3.22 | 2.24 | X2 | 1-2 | U |
| 20:30 Dinamo Tbilisi – VMFD Zalgiris Vilnius : | 2.01 | 3.18 | 3.83 | 1X | 1-0 | U |
| 20:30 ML Vitebsk – Sutjeska Niksic : | 1.71 | 3.74 | 4.52 | 1 | 2-1 | O |
| 20:30 Santa Coloma – Rapid Wien : | 11.50 | 6.55 | 1.20 | 1X | 2-1 | O |
| 20:30 Zimbru Chisinau – Noah Yerevan : | 4.43 | 3.70 | 1.73 | 2 | 1-2 | U |
| 20:30 BATE Borisov – Sion : | 14.50 | 5.70 | 1.21 | | | U |
|
| 20:30 Hammarby – Anderlecht : | 2.36 | 3.50 | 2.80 | 1X | 2-1 | U |
| 20:30 Sheriff Tiraspol – Maccabi Tel Aviv : | 3.36 | 3.36 | 2.12 | 1X | 2-1 | U |
| 20:30 Tromso – Hradec Kralove : | 1.55 | 4.35 | 5.20 | 1 | 2-1 | U |
| 20:30 Dynamo Kyiv – P.A.O.K. : | 2.90 | 3.25 | 2.41 | 1X | 2-1 | U |
|
| 21:00 Vaduz – Atletic d'Escaldes : | 1.30 | 5.05 | 9.65 | 1 | 3-0 | U |
| 21:15 FCSB – Auda : | 1.23 | 5.60 | 12.10 | 1 | 4-1 | U |
| 21:30 NK Varazdin – Jablonec : | 2.98 | 3.28 | 2.31 | 1X | 2-1 | U |
| 21:30 Paksi – Panathinaikos : | 5.28 | 4.70 | 1.49 | 1X | 2-1 | U |
| 21:30 Polissya Zhytomyr – Copenhagen : | 4.24 | 3.62 | 1.78 | 2 | 1-2 | U |
| 21:30 NK Aluminij – Dinamo City : | 2.84 | 3.38 | 2.35 | X2 | 0-1 | U |
| 21:30 Vojvodina Novi Sad – Ajax : | 5.51 | 4.05 | 1.55 | 2 | 1-2 | U |
|
| 21:30 Besiktas – Midtjylland : | 2.08 | 3.40 | 3.42 | 1 | 2-1 | U |
| 21:30 St. Gallen – Benfica : | 6.74 | 4.65 | 1.42 | 2 | 1-2 | O |
| 21:30 Twente – Ferencvarosi : | 1.65 | 3.88 | 4.93 | X2 | 1-2 | U |
|
| 22:00 Hapoel Tel Aviv – Ludogorets 1945 : | 3.06 | 3.04 | 2.40 | X2 | 0-1 | U |
| 22:00 Borac Banja Luka – Petrocub : | 1.44 | 4.55 | 6.28 | 1 | 2-1 | O |
| 22:00 LNZ – Gent : | 3.66 | 3.12 | 2.08 | 2 | 1-2 | U |
| 22:00 Lugano – Dukagjini : | 1.13 | 7.30 | 16.50 | 1 | 4-1 | U |
| 22:00 MSK Zilina – Katowice : | 2.56 | 3.34 | 2.57 | X2 | 1-2 | U |
| 22:15 Motherwell – Havnar Boltfelag : | 1.13 | 7.60 | 16.00 | 1 | 2-1 | O |
| 22:15 NK Bravo – Skendija : | 1.69 | 3.84 | 4.56 | 1 | 2-1 | O |
| 22:15 NSI Runavik – Koper : | 3.22 | 3.72 | 2.02 | 2 | 1-2 | U |
| 22:15 Rijeka – Derry City : | 1.13 | 7.20 | 18.50 | 1 | 4-1 | U |
| 22:15 Shelbourne – Nomme Kalju : | 1.33 | 4.70 | 9.20 | 1 | 2-1 | U |
| 22:30 Partizan Belgrade – UNA Strassen : | 1.22 | 5.80 | 12.30 | 1 | 2-1 | O |
| 22:30 Stjarnan – Ilves : | 2.50 | 3.72 | 2.44 | X2 | 1-2 | O |
|
| 22:30 Hajduk Split – Pafos : | 2.18 | 3.28 | 3.28 | 1X | 2-1 | U |
|
| 22:45 Valur – Zrinjski : | 2.26 | 3.48 | 2.92 | 1X | 1-0 | U |
|
| 02:00 Belgrano – Rosario Central : | 2.50 | 2.85 | 3.32 | 1X | 2-1 | U |
| 02:00 Club Atletico Sarmiento Junin – Argentinos Juniors : | 4.38 | 3.00 | 2.04 | X2 | 1-2 | U |
|
| 02:00 Botafogo de Futebol e Regatas – EC Vitoria Salvador : | 1.78 | 3.58 | 4.99 | 1 | 2-1 | U |
| 02:00 Corinthians Paulista – Clube do Remo : | 1.53 | 4.12 | 6.79 | 1 | 2-1 | U |
